MAPKAPK2

MAPKAPK2
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1KWP, 1NXK, 1NY3, 2JBO, 2JBP, 2OKR, 2ONL, 2OZA, 2P3G, 2PZY, 3A2C, 3FPM, 3FYJ, 3FYK, 3GOK, 3KA0, 3KC3, 3KGA, 3M2W, 3M42, 3R2B, 3R2Y, 3R30, 3WI6, 4TYH
معین‌کننده‌ها
نام‌های دیگر	MAPKAPK2, MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2, MAPK activated protein kinase 2
شناسه‌های بیرونی	OMIM: 602006 MGI: 109298 HomoloGene: 56412 GeneCards: MAPKAPK2
موقعیت ژن (موش) کروموزوم کروموزوم ۱ (موش) نوار 1|1 E4 شروع 130,981,437 bp پایان 131,025,563 bp
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • calmodulin-dependent protein kinase activity • signal transducer activity • nucleotide binding • transferase activity • kinase activity • calcium-dependent protein serine/threonine kinase activity • calmodulin binding • ATP binding • GO:0001948، GO:0016582 پیوند پروتئینی • protein kinase activity • protein serine/threonine kinase activity • mitogen-activated protein kinase binding ترکیبات سلولی • extracellular exosome • سیتوزول • میان‌تن • نوکلئوپلاسم • سیتوپلاسم • هسته یاخته فرایند زیستی • response to stress • MAPK cascade • regulation of mRNA stability • response to cytokine • GO:0035404 peptidyl-serine phosphorylation • cellular response to vascular endothelial growth factor stimulus • mRNA stabilization • protein autophosphorylation • 3'-UTR-mediated mRNA stabilization • cellular response to DNA damage stimulus • inner ear development • p38MAPK cascade • Ras protein signal transduction • leukotriene metabolic process • regulation of cellular response to heat • فسفرگیری • protein phosphorylation • regulation of interleukin-6 production • vascular endothelial growth factor receptor signaling pathway • response to lipopolysaccharide • inflammatory response • macropinocytosis • regulation of tumor necrosis factor production • toll-like receptor signaling pathway • GO:0007243 intracellular signal transduction منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	9261	17164
آنسامبل	ENSG00000162889	ENSMUSG00000016528
یونی‌پروت	P49137	P49138
RefSeq (mRNA)	NM_004759، NM_032960، XM_017002810، XM_047434418 XM_005273353، NM_004759، NM_032960، XM_017002810، XM_047434418	NM_008551
RefSeq (پروتئین)	NP_116584، XP_005273410، XP_016858299 NP_004750، NP_116584، XP_005273410، XP_016858299	NP_032577
موقعیت (UCSC)	ن/م	Chr : 130.98 – 131.03 Mb
جستجوی PubMed
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

پروتئین کیناز ۲ فعال شده توسط MAP کیناز (انگلیسی: MAPKAPK2) یک پروتئین است که در انسان توسط ژن «MAPKAPK2» کُدگذاری می‌شود و جزئی از خانوادهٔ پروتئین کیناز اختصاصی سرین/ترئونین است.

این پروتئین یکی از میانجی‌های آغاز فعالیت فاکتورهای فنوتیپ ترشحی مرتبط با پیری (SASP) توسط MTOR است. فعالیت MTOR سطح اینترلوکین ۱ آلفا را افزایش می‌دهد و اینکار با واسطهٔ MAPKAPK2 انجام می‌شود.

منابع

• مشارکت‌کنندگان ویکی‌پدیا. «MAPKAPK2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر

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