FGF7

FGF7
معین‌کننده‌ها
نام‌های دیگر	FGF7, HBGF-7, KGF, fibroblast growth factor 7
شناسه‌های بیرونی	OMIM: 148180 MGI: 95521 HomoloGene: 7316 GeneCards: FGF7
موقعیت ژن (موش)
کروموزوم	کروموزوم ۲ (موش)
پایان	125,933,105 bp
الگوی گسترش RNA
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• heparin binding; • fibroblast growth factor receptor binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • chemoattractant activity; • growth factor activity; • 1-phosphatidylinositol-3-kinase activity; • protein tyrosine kinase activity; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity;
ترکیبات سلولی	• دستگاه گلژی; • extracellular region;
فرایند زیستی	• actin cytoskeleton reorganization; • mesenchymal cell proliferation; • positive regulation of keratinocyte proliferation; • positive regulation of epithelial cell proliferation involved in lung morphogenesis; • secretion by lung epithelial cell involved in lung growth; • positive regulation of epithelial cell proliferation; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; • MAPK cascade; • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated; • fibroblast growth factor receptor signaling pathway; • positive regulation of keratinocyte migration; • protein localization to cell surface; • response to wounding; • positive regulation of cell population proliferation; • epidermis development; • positive regulation of peptidyl-tyrosine phosphorylation; • hair follicle morphogenesis; • positive chemotaxis; • positive regulation of cell division; • GO:0072468 ورارسانی پیام; • branching involved in salivary gland morphogenesis; • phosphatidylinositol phosphate biosynthetic process; • peptidyl-tyrosine phosphorylation; • phosphatidylinositol-3-phosphate biosynthetic process; • regulation of signaling receptor activity; • positive regulation of protein kinase B signaling;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	2252
	14178
	ENSG00000140285
	ENSMUSG00000027208
	P21781
	P36363
	NM_002009
	NM_008008
	NP_002000
	NP_032034
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

فاکتور رشد فیبروبلاست ۷ (انگلیسی: Fibroblast growth factor 7) که با نام فاکتور رشد کراتینوسیت هم شناخته می‌شود یک پروتئین است که در انسان توسط ژن «FGF7» کُدگذاری می‌شود.^[۴]^[۵]^[۶]

مطالعات انجام‌شده بر روی موش‌ها نشان داده‌است که این پروتئین در شکل‌گیری بافت پوششی، بازسازی لایهٔ پوششی زخم‌ها، رشد مو، و به‌وجود آمدن ریه‌ها در مراحل اولیهٔ جنینی نقش دارد.^[۶]

این مولکول با پروتئین پرلیکن تعامل پروتئین-پروتئین دارد.^[۷]

منابع[ویرایش]

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027208 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (Mar 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome. 6 (3): 196–7. doi:10.1007/BF00293012. PMID 7749227.
↑ Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (Oct 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9287–91. doi:10.1073/pnas.89.19.9287. PMC 50111. PMID 1409637.
↑ ^۶٫۰ ^۶٫۱ "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)".
↑ Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.

مشارکت‌کنندگان ویکی‌پدیا. «FGF7». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۴ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر[ویرایش]

Beer HD, Gassmann MG, Munz B, Steiling H, Engelhardt F, Bleuel K, Werner S (Dec 2000). "Expression and function of keratinocyte growth factor and activin in skin morphogenesis and cutaneous wound repair". The Journal of Investigative Dermatology. Symposium Proceedings. 5 (1): 34–9. doi:10.1046/j.1087-0024.2000.00009.x. PMID 11147673.
Ware LB, Matthay MA (May 2002). "Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair". American Journal of Physiology. Lung Cellular and Molecular Physiology. 282 (5): L924–40. doi:10.1152/ajplung.00439.2001. PMID 11943656.
Finch PW, Rubin JS (2004). "Keratinocyte growth factor/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair". Advances in Cancer Research. 91: 69–136. doi:10.1016/S0065-230X(04)91003-2. ISBN 978-0-12-006691-9. PMID 15327889. {{cite journal}}: Cite journal requires |journal= (help)
Ishibashi T, Bottaro DP, Chan A, Miki T, Aaronson SA (Dec 1992). "Expression cloning of a human dual-specificity phosphatase". Proceedings of the National Academy of Sciences of the United States of America. 89 (24): 12170–4. doi:10.1073/pnas.89.24.12170. PMC 50720. PMID 1281549.
Aaronson SA, Bottaro DP, Miki T, Ron D, Finch PW, Fleming TP, Ahn J, Taylor WG, Rubin JS (1992). "Keratinocyte growth factor. A fibroblast growth factor family member with unusual target cell specificity". Annals of the New York Academy of Sciences. 638: 62–77. doi:10.1111/j.1749-6632.1991.tb49018.x. PMID 1664700.
Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (Aug 1989). "Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth". Science. 245 (4919): 752–5. doi:10.1126/science.2475908. PMID 2475908.
Rubin JS, Osada H, Finch PW, Taylor WG, Rudikoff S, Aaronson SA (Feb 1989). "Purification and characterization of a newly identified growth factor specific for epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 802–6. doi:10.1073/pnas.86.3.802. PMC 286565. PMID 2915979.
Ron D, Reich R, Chedid M, Lengel C, Cohen OE, Chan AM, Neufeld G, Miki T, Tronick SR (Mar 1993). "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor". The Journal of Biological Chemistry. 268 (8): 5388–94. PMID 7680645.
Yan G, Fukabori Y, McBride G, Nikolaropolous S, McKeehan WL (Aug 1993). "Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy". Molecular and Cellular Biology. 13 (8): 4513–22. doi:10.1128/MCB.13.8.4513. PMC 360063. PMID 7687739.
Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT (Nov 1994). "The function of KGF in morphogenesis of epithelium and reepithelialization of wounds". Science. 266 (5186): 819–22. doi:10.1126/science.7973639. PMID 7973639.
Wilson SE, Walker JW, Chwang EL, He YG (Jul 1993). "Hepatocyte growth factor, keratinocyte growth factor, their receptors, fibroblast growth factor receptor-2, and the cells of the cornea". Investigative Ophthalmology & Visual Science. 34 (8): 2544–61. PMID 8392040.
Guo L, Degenstein L, Fuchs E (Jan 1996). "Keratinocyte growth factor is required for hair development but not for wound healing". Genes & Development. 10 (2): 165–75. doi:10.1101/gad.10.2.165. PMID 8566750.
Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (Jun 1996). "Receptor specificity of the fibroblast growth factor family". The Journal of Biological Chemistry. 271 (25): 15292–7. doi:10.1074/jbc.271.25.15292. PMID 8663044.
Post M, Souza P, Liu J, Tseu I, Wang J, Kuliszewski M, Tanswell AK (Oct 1996). "Keratinocyte growth factor and its receptor are involved in regulating early lung branching". Development. 122 (10): 3107–15. PMID 8898224.
Zimonjic DB, Kelley MJ, Rubin JS, Aaronson SA, Popescu NC (Oct 1997). "Fluorescence in situ hybridization analysis of keratinocyte growth factor gene amplification and dispersion in evolution of great apes and humans". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11461–5. doi:10.1073/pnas.94.21.11461. PMC 23506. PMID 9326632.
Winkles JA, Alberts GF, Chedid M, Taylor WG, DeMartino S, Rubin JS (Dec 1997). "Differential expression of the keratinocyte growth factor (KGF) and KGF receptor genes in human vascular smooth muscle cells and arteries". Journal of Cellular Physiology. 173 (3): 380–6. doi:10.1002/(SICI)1097-4652(199712)173:3<380::AID-JCP10>3.0.CO;2-G. PMID 9369951.
Ishibashi T, Tanaka T, Nibu K, Ishimoto S, Kaga K (Oct 1998). "Keratinocyte growth factor and its receptor messenger RNA expression in nasal mucosa and nasal polyps". The Annals of Otology, Rhinology, and Laryngology. 107 (10 Pt 1): 885–90. doi:10.1177/000348949810701013. PMID 9794620.
Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.

این یک مقالهٔ خرد زیست‌شناسی مولکولی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000027208 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7749227-4] Mattei MG, deLapeyrière O, Bresnick J, Dickson C, Birnbaum D, Mason I (Mar 1995). "Mouse Fgf7 (fibroblast growth factor 7) and Fgf8 (fibroblast growth factor 8) genes map to chromosomes 2 and 19 respectively". Mammalian Genome. 6 (3): 196–7. doi:10.1007/BF00293012. PMID 7749227.

[pmid1409637-5] Kelley MJ, Pech M, Seuanez HN, Rubin JS, O'Brien SJ, Aaronson SA (Oct 1992). "Emergence of the keratinocyte growth factor multigene family during the great ape radiation". Proceedings of the National Academy of Sciences of the United States of America. 89 (19): 9287–91. doi:10.1073/pnas.89.19.9287. PMC 50111. PMID 1409637.

[entrez-6] ۶٫۰ ^۶٫۱ "Entrez Gene: FGF7 fibroblast growth factor 7 (keratinocyte growth factor)".

[pmid10702276-7] Mongiat M, Taylor K, Otto J, Aho S, Uitto J, Whitelock JM, Iozzo RV (Mar 2000). "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". The Journal of Biological Chemistry. 275 (10): 7095–100. doi:10.1074/jbc.275.10.7095. PMID 10702276.

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